Subglottic stenosis in Wegener's granulomatosis: development during cyclophosphamide treatment with response to carbon dioxide laser therapy.
نویسندگان
چکیده
A patient with Wegener's granulomatosis rapidly developed a circumferential subglottic stenosis while on a cyclophosphamide regimen that had caused resolution of systemic symptoms and pulmonary infiltrates. The stenosis developed in the area of previously noted tracheal ulceration and responded satisfactorily to carbon dioxide laser therapy.
منابع مشابه
Endoscopic Laser Surgery for Subglottic Stenosis in Wegener's Granulomatosis
PURPOSE Wegener's granulomatosis (WG) is a rare multisystem inflammatory disease, which infrequently involves the subglottic area and trachea. Treatment usually involves the use of immunosuppressive agents with corticosteroids. Some patients, however, continue to have symptoms of airway obstruction after clinical remission following the standard therapeutic regimen. OBJECTIVE To investigate l...
متن کاملLack of efficacy of rituximab in Wegener's granulomatosis with refractory granulomatous manifestations.
OBJECTIVE To investigate the safety and efficacy of rituximab (RTX) in patients with refractory Wegener's granulomatosis (WG). PATIENTS AND METHODS Eight consecutive patients with active refractory WG were included. In all patients disease activity had persisted despite standard treatment with cyclophosphamide and prednisolone, as well as tumour necrosis factor alpha blockade 3 months before ...
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OBJECTIVE Describe the management of subglottic stenosis in a patient with Wegener's granulomatosis. MATERIAL AND METHOD Case report. RESULTS We report the case of a 26-year-old woman who presented Wegener granulomatosis and subglottic stenosis, with renal, skin, oropharyngeal, nasal, and paranasal locations. Medical treatment had cured all the locations except the subglottic stenosis. An e...
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Wegener's granulomatosis (WG) is a disease caused by necrotising vasculitis of small and middle blood vessels of upper and lower respiratory tract and kidneys of unknown etiology. ENT symptoms develop in more than 90% of patients and tracheobronchial involvement occurs in about 20% of patients, most often as a subglottic stenosis. Subglottic stenosis occurs usually as a late complication of dis...
متن کاملSubglottic stenosis: a ten-year review of treatment outcomes.
OBJECTIVES/HYPOTHESIS To evaluate the endoscopic surgical management of adult subglottic stenosis and describe treatment outcomes. STUDY DESIGN Retrospective review. METHODS Ten-year review of adult patients with subglottic stenosis. RESULTS Ninety-two adults (23 male, 69 female) with subglottic stenosis underwent 247 endoscopic dilations between 2001 and 2010. The mean age was 48 years a...
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ورودعنوان ژورنال:
- Thorax
دوره 45 4 شماره
صفحات -
تاریخ انتشار 1990